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 TIBICO - StudyThe TIBICO-Study was initiated in 2009 as an monozentric, non-randomized pilot trail. This preliminary study results were published. After 2011 the study was extended to a multicentered RCT. 
 Primary outcome is the decrease in capillary pCO2 in stable hypercapnic COPD patients. For this purpose patients receive NHF or NIV 6 weeks in a randomized order. Secondary outcomes are changes in whole blood gas analysis, SGRQ, SAE, 6-MWT etc.. 
 If you have questions do not hesitate to contact us! 
 Email: tibico@web.de 
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